Detalhe da pesquisa
1.
The inhibitory receptor TIM-3 limits activation of the cGAS-STING pathway in intra-tumoral dendritic cells by suppressing extracellular DNA uptake.
Immunity
; 54(6): 1154-1167.e7, 2021 06 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-33979578
2.
Phase I studies of AZD1208, a proviral integration Moloney virus kinase inhibitor in solid and haematological cancers.
Br J Cancer
; 118(11): 1425-1433, 2018 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-29765150
3.
AZD1208, a potent and selective pan-Pim kinase inhibitor, demonstrates efficacy in preclinical models of acute myeloid leukemia.
Blood
; 123(6): 905-13, 2014 Feb 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-24363397
4.
Safety, antitumor activity, and pharmacokinetics of dostarlimab, an anti-PD-1, in patients with advanced solid tumors: a dose-escalation phase 1 trial.
Cancer Chemother Pharmacol
; 89(1): 93-103, 2022 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-34750637
5.
Expression Analysis and Significance of PD-1, LAG-3, and TIM-3 in Human Non-Small Cell Lung Cancer Using Spatially Resolved and Multiparametric Single-Cell Analysis.
Clin Cancer Res
; 25(15): 4663-4673, 2019 08 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-31053602
6.
PIM1 kinase regulates cell death, tumor growth and chemotherapy response in triple-negative breast cancer.
Nat Med
; 22(11): 1303-1313, 2016 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-27775704
7.
Increased CpG methylation of the estrogen receptor gene in BRCA1-linked estrogen receptor-negative breast cancers.
Oncogene
; 21(46): 7034-41, 2002 Oct 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-12370825
8.
The Pim-1 protein kinase is an important regulator of MET receptor tyrosine kinase levels and signaling.
Mol Cell Biol
; 34(13): 2517-32, 2014 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-24777602
9.
Novel neutralizing hedgehog antibody MEDI-5304 exhibits antitumor activity by inhibiting paracrine hedgehog signaling.
Mol Cancer Ther
; 13(2): 386-98, 2014 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-24344235
10.
Erratum: PIM1 kinase regulates cell death, tumor growth and chemotherapy response in triple-negative breast cancer.
Nat Med
; 23(6): 788, 2017 06 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-28586336
11.
Erratum: PIM1 kinase regulates cell death, tumor growth and chemotherapy response in triple-negative breast cancer.
Nat Med
; 23(4): 526, 2017 Apr 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-28388604
12.
The JAK2 inhibitor AZD1480 potently blocks Stat3 signaling and oncogenesis in solid tumors.
Cancer Cell
; 16(6): 487-97, 2009 Dec 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-19962667
13.
BRCA1 splice variants exhibit overlapping and distinct transcriptional transactivation activities.
J Cell Biochem
; 89(1): 120-32, 2003 May 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-12682913